Not too long ago, it was commonplace for people across the globe to die horrific, painful, disfiguring deaths from illnesses they couldn't control.
Today, many of those diseases have begun to disappear.
In many parts of the developed world, some of the worst of these diseases are gone completely. Their disappearance is a testament to the power of vaccines.
Yet these diseases still exist in many other countries, and public health workers are working hard to contain their spread and increase peoples' access to the shots and pills we often take for granted.
Measles
Like smallpox, measles is highly contagious. Its most serious complications include blindness, severe diarrhea, serious respiratory infections, and encephalitis, a severe infection that causes brain swelling.
New research also finds that measles can have a crippling, sometimes long term effect on children's immune systems for years after an initial infection, leaving them susceptible to other infectious diseases. The vaccine, the research suggests, protects against this.
The good news is that aside from a scary outbreak in California last December — which research suggests was caused by a growing number of parents refusing vaccinations for their children — measles has been largely eliminated in most affluent countries, and deaths from measles across the globe have dropped by 75% since 2000.
Still, the virus is still common in many developing countries, particularly in parts of Africa and Asia, but the WHO has plans to eliminate the disease globally by 2020.
Rubella
Rubella is a highly contagious disease whose worst effects are seen in fetuses within their mother's first trimester. In young people and adults, rubella most often causes an all-over body rash and cold-like symptoms that typically clear in a few days.
In fetuses, though, rubella can cause deafness, blindness, and severe brain damage. A 1964-1965 rubella outbreak in the US caused roughly 11,250 abortions, 2,100 stillborns, and 20,000 babies born with defects.
Last month, though, rubella was officially declared eliminated from the Americas, a region defined by the World Health Organization to include the US, Canada, Cuba, and Central and South America.
Still, roughly 120,000 children a year are born across the globe with severe rubella-related birth defects, so there's still work to do.
Polio
Polio is a crippling and sometimes deadly infectious disease. There is no cure.
Most cases of the disease — somewhere between 90% and 95% — cause no symptoms, making it easy for an infected person to get another person sick. In those cases, people can recover within a few weeks.
In about 1% of cases, however, or around 1 in 200 cases, polio can leave its sufferers with permanent physical disabilities. In these cases, the virus spreads along the pathways inside the nerve fibers in the spinal cord, brain stem, or motor cortex, the movement-controlling part of the brain. Once inside, polio eats away at the nerves inside these parts of the body that allow us to move. Among people with polio who become paralyzed, about 5% to 10% die when the muscles that control their breathing are rendered immobile by the virus.
In the last 3 decades, cases of polio across the globe have plummeted, dropping nearly 99% since 1988. That year, the World Health Assembly resolved to globally eradicate polio, and several international health organizations joined in the effort to disseminate the vaccine worldwide.
As of last year, just 3 countries still see regular cases of polio: Nigeria, Pakistan, and Afghanistan, and efforts are underway to eradicate the disease completely.
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